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Early WC reduction accounted for an estimated 33% of the effect
While palmitate and serine are the canonical substrates for SPT, depending on the enzymes isoform, various fatty acids (stearic or myristic acid) and amino acids (alanine or glycine) can also be used, resulting in the formation of atypical sphingoid bases that increases the diversity of sphingolipids (27)
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Continued clinical research, systematic evaluation, and knowledge translation are essential to ensure safe, effective, and patient-centered applications of TEAM-based interventions in cancer care
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